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Victoza

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Liraglutide, sold under the brand name Victoza among others, is a prescription used to treat diabetes mellitus type 2 and obesity. In diabetes, it is a less favoured specialist contrasted with metformin. Its consequences for long haul wellbeing results like coronary illness and future are unclear. It is given by infusion under the skin.

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Liraglutide, sold under the brand name Victoza among others, is a prescription used to treat diabetes mellitus type 2 and obesity.[1] In diabetes it is a less favored specialist contrasted with metformin.[1][2] Its consequences for long haul wellbeing results like coronary illness and future are unclear.[1] [3]It is given by infusion under the skin.[1]

Normal aftereffects incorporate low glucose, queasiness, dazedness, stomach torment, and agony at the site of injection.[1] Other genuine secondary effects might incorporate medullary thyroid malignancy, angioedema, pancreatitis, gallbladder illness, and kidney problems.[1] Use in pregnancy and breastfeeding is of indistinct safety.[1] Liraglutide is a glucagon-like peptide-1 receptor agonist (GLP-1 receptor agonist) otherwise called incretin mimetics.[1] It works by expanding insulin discharge from the pancreas and diminishes over the top glucagon release.[1]

Liraglutide was endorsed for clinical use in the European Union in 2009, and in the United States in 2010.[4][5] In 2018, it was the 143rd most generally recommended medicine in the United States, with multiple million remedies.

Clinical employments

Liraglutide is a prescription utilized for the treatment of type 2 diabetes or obesity.[1]

Type 2 diabetes

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Liraglutide further develops control of blood glucose.[8] As of 2017 it is muddled if incretin mimetics like liraglutide influence an individual’s danger of death.[9]

In diabetes it is a less favored agent.[1] It might be utilized in those in who metformin and another antidiabetic prescription, for example, a sulfonylurea are not sufficient.[2]

Corpulence

Liraglutide may likewise be utilized along with diet and exercise for constant weight the board in grown-up patients.[1] The weight record (BMI) should be more prominent than 30 kg/m2, or more noteworthy than 27 kg/m2 along with hypertension, type 2 diabetes mellitus, or dyslipidemia.[1]

It is obscure if the weight reduction will be super durable. Craving concealment might be impermanent and hunger may return regardless of whether one keeps on utilizing liraglutide following 56 weeks.

Antagonistic impacts

Thyroid malignant growth

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At openings multiple times more prominent than those utilized in people, liraglutide caused a measurably huge expansion in thyroid growths in rodents. The clinical significance of these discoveries is unknown.[10] In clinical preliminaries, the pace of thyroid cancers in patients treated with liraglutide was 1.3 per 1000 patient years (4 individuals) contrasted with 1.0 per 1000 patients (1 individual) in examination gatherings. The sole individual in the comparator gathering and four of the five people in the liraglutide bunch had serum markers (raised calcitonin) reminiscent of prior illness at baseline.[10]

The FDA said serum calcitonin, a biomarker of medullary thyroid malignancy, was marginally expanded in liraglutide patients, yet inside typical reaches, and it required continuous checking for quite a long time in a disease registry.[11]

Pancreatitis

In 2013, a gathering at Johns Hopkins announced an obviously measurably huge relationship between hospitalization for intense pancreatitis and earlier therapy with GLP-1 subordinates, (for example, exenatide) and DPP-4 inhibitors, (for example, sitagliptin).[12] accordingly, the United States FDA and the European Medicines Agency directed an audit of all accessible information in regards to the conceivable association between incretin mimetics and pancreatitis or pancreatic malignant growth. In a joint 2014 letter to the New England Journal of Medicine, the offices reasoned that “A pooled examination of information from 14,611 patients with type 2 diabetes from 25 clinical preliminaries in the sitagliptin data set gave no convincing proof of an expanded danger of pancreatitis or pancreatic malignant growth” and “The two organizations concur that attestations concerning a causal relationship between incretin-based medications and pancreatitis or pancreatic disease, as communicated as of late in the logical writing and in the media, are conflicting with the flow information. The FDA and the EMA have not arrived at a last resolution as of now in regards to such a causal relationship. Albeit the entirety of the information that have been inspected gives consolation, pancreatitis will keep on being viewed as a danger related with these medications until more information are accessible; the two offices keep on researching this security signal

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Additional information

Quantity

6mg/ml (pack 2 pens), 6mg/ml (pack 3 pens)

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